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Wikipedia - Darifenacin

Darifenacin
Systematic (IUPAC) name
(S)-2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl] pyrrolidin-3-yl] -2,2-diphenyl-acetamide
Identifiers
CAS number 133099-04-4
ATC code G04BD10
PubChem CID 444031
DrugBank APRD00903
ChemSpider 392054
Chemical data
Formula C28H30N2O2 
Mol. mass 426.55 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 15 to 19% (dose-dependent)
Protein binding 98%
Metabolism Hepatic (CYP2D6- and CYP3A4-mediated)
Half-life 13 to 19 hours
Excretion Renal (60%) and biliary (40%)
Therapeutic considerations
Pregnancy cat. B3(AU) C(US)
Legal status POM (UK) ?-only (US)
Routes Oral
 YesY(what is this?)  (verify)

Darifenacin (trade name Enablex in US and Canada, Emselex in Europe) is a medication used to treat urinary incontinence. It is marketed by Novartis.

Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate. It should not be used in people with urinary retention.

It is not known whether this selectivity for the M3 receptor translates into any clinical advantage when treating symptoms of overactive bladder syndrome.[1]

[edit] Clinical uses

Darifenacin is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.

[edit] References

  1. ^ SPC for emselex-revised on 29/11/06 (available at http://www.medicines.org.uk)

[edit] External links

v • d • e
Urologicals, including antispasmodics (G04B)
Acidifiers
Urinary antispasmodics
(primarily antimuscarinics)
For erectile dysfunction
Others
Other urologicals
Stub icon This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Darifenacin"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Darifenacin".

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